Since 1997, Longo has been a faculty member at the USC Davis School of Gerontology and Ethel Percy Andrus Gerontology Center. He is a member of the formation of USC's Biology of Aging program as well as the director of the USC Longevity Institute, also launched the USC Davis School of Gerontology's first study-abroad program, a summer class in the nutrition and genetics of aging in Italy.
In 2011, he was profiled on Through the Wormhole with Morgan Freeman for his longevity-related research.
Is an Italian-American biogerontologist and cell biologist.
He is known for his studies on the role of fasting and nutrient response genes on cellular protection aging and diseases and for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes.
He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biological Sciences as well as serving as the director of the USC Longevity Institute.